Perry's Essay

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Successful Harvard Medical School Essay

By integrating skills I have gained from conducting translational neuroscience and organic chemistry research, caring for people with Alzheimer’s disease (AD), and studying the brain on molecular, cellular, and systems levels, I want to help alleviate one of society’s most burdensome and significant issues: mental illness.

My interest in the brain started in high school when I had the opportunity to investigate the neural correlates of music performance with electroencephalography (EEG) in Scott Makeig’s computational neuroscience lab at UCSD. An avid musician, I was fascinated by how the brain could represent complex behaviors such as emotional perception of music. This fascination with neural processing eventually pushed me to pursue neurobiology at Harvard.

My freshman year I saw a flier calling for student volunteers to work with people with AD. Interested in neurology, I saw this as a perfect opportunity to learn more about brain pathophysiology. Every week I would go to the nursing home to meet my resident— talking, performing music, or even playing crochet. I learned a lot about caring for people with dementia, experiencing firsthand how simple actions such as communicating with facial expressions and touch, and being flexible in conversations, made a big difference. As I learned these lessons, however, my assigned resident also became my friend. I found myself practicing piano pieces for the first time in years to play for her. Being recognized, a simple action many of us take for granted, became a highlight of my day. When I attended lectures about AD, I no longer visualized patients without faces, but instead saw my friend. She brought personal relevance to my previously abstract academic world, and I began to see medicine as a future vocation.

I wanted to learn more about the interface of academics and medicine and looked for ways to study the mechanisms of the brain in a clinical context. I found such an opportunity in Diego Pizzagalli’s translational neuroscience lab at McLean Hospital, where I utilized EEG to study clinical depression. In the process, I gained direct insight on the current state of psychiatric research, the clinical research environment, and how to think critically about unsolved problems. More importantly, by applying my research skills and neurobiology coursework in a clinical context, I experienced firsthand how my passion for academic learning and intellectual curiosity could directly fuel a career in medicine.

In order to better understand clinical practice, I contacted physicians at Salinas Valley Memorial Healthcare System and Massachusetts General Hospital where I shadowed neurologists and cardiologists. I observed regular check-ups, emergency room procedures, surgeries, and the differences between private clinic and hospital environments. The most memorable aspects, however, were the raw vulnerabilities patients revealed. I saw a wife emotionally leave her husband before heart surgery and watched a surgeon complete the procedure. I listened to a distressed couple discuss options for their disabled child because home care was too demanding and met a woman frustrated by her recent aphasia. The thought that I might be able to respond to these vulnerabilities as a practicing physician was powerful.

In my sophomore year, I attended a lecture titled “Resuscitating Psychiatric Drug Discovery” by Dr. Steven Hyman, former Director of the National Institute of Mental Health. Anticipating hearing about exciting developments from the head of psychiatric research at the Broad Institute, I was surprised to hear him instead state that there have been no new mechanisms in psychiatric drug development since the 1950s. Aspiring to enter psychiatry, I was frustrated but thought of ways to train myself to address this pressing need. One of his main points was that drugs bind to brain receptors and interact with catalytic enzymes, yet there is little emphasis placed on the catalysis involved in prescribed drugs. To develop this mechanistic intuition and deepen my understanding of catalytic chemistry, I joined Eric Jacobsen’s organic chemistry lab where I have been working to design and discover small-molecule catalyst systems for the ester hydrolysis reaction. Designing, synthesizing, and screening catalysts parallels much of the drug discovery process, and I hope to be able to apply these skills in the future to psychiatric drug development.

I am committed to pursuing a career in medicine. My coursework has prepared me to approach medicine with perspectives from psychology to organic chemistry, and caring for nursing home residents with Alzheimer’s disease has given me intimate familiarity with patient care. Shadowing has taught me the physician’s perspective, and clinical research has shown me how to mediate collaboration between medicine and academia. In medical school, I look forward to exploring how I can integrate my skill sets to best respond to patient vulnerabilities. Although I am most interested in mental health-related fields, I am eager to explore different fields of medicine and to broaden my knowledge in both the lab and the clinic. By doing so, I hope to learn how to maximize my contribution to medicine and my impact on future patients.

Professional Review by My Med Mentor

This personal statement beautifully displays the power of storytelling in an engaging and meaningful way. Perry’s passion for medicine and journey to medicine, with a focus on mental health, is clearly portrayed. Perry is very creative in showcasing their extracurricular activities, extent of involvement, and skills by highlighting memorable stories and the impact on their journey. Instead of regurgitating their resume, they have meticulously selected significant, longitudinal experiences to display their passion for medicine. This is a key step to consider when choosing which experiences to discuss in the personal statement. The reader can tell that Perry’s journey was filled with introspection and reflection as their involvement in various activities was purposeful. This narrative is a phenomenal example of the importance of showing one’s strengths versus telling them.

My Med Mentor ensures applicants receive personalized feedback. Using that approach, we would advise that while this statement displays many strengths, there is room for improvement. As consultants who have been members of the admissions committee and have helped countless applicants in their journey, we are able to provide invaluable and critical feedback. For this statement, Perry’s significant focus on their research experiences comes at the cost of overshadowing their clinical experiences. As such, we would recommend including more clinical experiences to demonstrate their ability to be an astute clinician. Perry has a special interest in mental health which is clear to the reader, however, it is imperative to also highlight the diversity and breadth of their clinical experiences to show a more well-rounded applicant.

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